The book describes the latest methods and novel technologies being developed for the frabication of LOC devices and new approaches for fluid control and manipulation. The book described and discusses the newest technologies for the prototyping of devices, including replication and direct machining methods of fabrication. It covers all aspects of fabrication laser micromachining, silicon and glass micromachining. PMMA and COC micro-fluidic substrates, and xurography (LOC prototyping with a cutting plotter). Additionally, it focuses on fluid control and manipulation for LOC systems, As well as providing examples of the use of pumps in microfluidics topics covered include electro-kinetic pumping (electroosmois), electrochamical pumping and electro-wetting and the fabrication of a microchip for rapid polymerase chain reaction (PCR). This comprehensive volume presents the current technologies in teh field and includes theoretical and technical information to enable both the understanding of the technology and the reproduction of experiments. The book aims to help the reader to understand current LOC technologies, to perform similar experiments, to design new LOC systems and to develop new methodolofies and applications. An essential book for biologists and clinicians using LOC technology and developing applications and also for engineering, chemical and physical science researchers developing analytical technologies. The book will also be useful as a teaching tool for bioengineering, biomedical engineering and biology.
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